Who are advised karyotyping before conception?
Karyotyping can be advised to detect a variety of genetic disorders in specific clinical scenarios, few of them are:
- Premature ovarian failure – women attaining menopause early.
- Couples having recurrent miscarriages
- Couple facing problems in conceiving (infertility)
- Few sperms in the male partner
- Couple having history of delivering children with specific disorders
- Couple terminating pregnancy due to multiple congenital defects in the foetus.
- Advanced Maternal Age – Women over 35 years of age, those with a previous affected child, and those with a positive family history have a higher risk of chromosomal problems and miscarriage.
- Familial Associations with Specific Diseases
- Racial or Ethnic Associations to Specific Diseases
- Congenital bilateral absence of vas deferens in the male partner