Sperm DNA damage may occur by any of these processes
In men, the major contribution is sperm in fertility. The factors for sperm DNA fragmentation is oxidative stress, which can be associated with one or more of the following:
The interior of a sperm cell contains genetic material which mixes with the egg cell DNA for successful fertilization and normal embryo development. If the fertilizing sperm has high DNA fragmentation it may not fertilize with the egg.
In short it may lead to male subfertility, IVF failure and miscarriage. Routinely a semen analysis does not check the percentage of fragmentation in DNA. It requires a special test which can differentiate between normal and fragmented DNA.
A number of sperm DNA fragmentation tests are available at present. These are available at reproductive health hospitals and fertility centers. Some of them are:
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