Cholelithiasis
The prevalence of cholelithiasis is significant among obese teenagers, and the link is stronger in girls than in boys. Cholelithiasis is caused by increased cholesterol production and bile cholesterol saturation in obese adolescents. Cholelithiasis becomes more common when one loses weight. Obesity may be linked to nearly half of all cholecystitis cases in teenagers.
Polycystic Ovary Disease
Obesity is usually linked to polycystic ovarian syndrome (PCOS). Obesity may affect up to 30% of PCOD women. PCOD is frequently accompanied by hyperandrogenism and hyperinsulinemia. Obesity raises the risk of PCOD by increasing insulin resistance and compensatory hyperinsulinemia, which increases androgen synthesis while decreasing sex hormone-binding globulin, increasing androgen bioavailability. Adolescents with PCOD are more likely to develop metabolic syndrome and glucose intolerance. Weight loss is an important therapy goal for obese adolescents with PCOD.