What is DNA Fragmentation?
The advance of molecular biology and genomics made a quantum change in the management of many medical conditions. Although their role in infertility lacks clarity, many fertility specialists apply them to improve success.
These tools and tests are very useful in conditions like cystic fibrosis, non-obstructive azoospermia. In addition a sperm DNA fragmentation test helps tp predict the probability of success in IVF treatment. These are diagnostic tests, but their role in therapy are still under evaluation.
What happens when you have high DNA fragmentation?
A DNA fragmentation test shows the percentage of spermatozoa in the semen with damaged DNA. DNA is the component of the cell that decides all features and transmits the same to the offspring. This test indicates the fertility potential of a given semen sample. But unfortunately, it is difficult to determine the quantity of unfragmented sperm for natural conception.
more than 50% good spermatozoon is required for natural conception. DNA fragmentation is a physiological process in sperm cells. Aging sperms undergo a type of intracellular degeneration called apoptosis.
Upto 50% of cells showing DNA fragmentation is natural rather than any disease process. Unless the sample has 100% DNA fragmentation, it may be impossible to call the sample sterile.